Electrochemical Behaviour of Fourth-generation Fluoroquinolone Antibacterial Drug Moxifloxacin by Dc Polarography and Cyclic Voltammetry

Electrochemical behaviour of fluoroquinolone Antibiotic drug, moxifloxacin hydrochloride has been studied in aqueous medium using DC polarography and cyclic voltammetry. Moxifloxacin exhibits single well-defined cathodic peak in all the buffers like acetate buffer, phosphate buffer and B.R.buffer. The characteristics of the peak have been examined at different concentrations, pH and scan rates. This behaviour may be attributed to the reduction of the C=O double bond of reactant species in the acidic and basic medium. The experimental result shows that the reduction is irreversible and diffusion controlled. A mechanism has been proposed for the reduction of the sample.